Abstract
We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC).
DRB1*100101
was positively associated, while
DRB1*140101
,
DRB1*150101
, and
DQB1*060101
were negatively associated, with VOC. Both susceptible (
DRB1*100101
-
DQB1*050101
) and protective (
DRB1*110101
-
DQB1*030101
and
DRB1*150101
-
DQB1*060101
) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.