Abstract
Pelletization methods like solution layering, suspension layering or powder layering and extrusion-spheronization process is the most frequently used method for producing spherical pellets which utilizes a granulating liquid such as water, requires drying steps which is time consuming. Many drugs exhibit stability problem due to the presence of water during processing and residual water during storage. In addition to that pellets produced by these techniques exhibit rapid drug release and require a film coating to provide controlled release properties. Hot melt extrusion and freeze pelletization technique is receiving a great deal of attention as alternative technique over other techniques which need water during processing and drying steps. This article reviews the recent finding in the preparation of pellets by these novel techniques.