Abstract
This review illustrates the potential development and delivery of the organometallic half sandwiched Ruthenium(II) arene complexes using carrier protein human serum albumin (HSA) for the selective delivery in the cancer regimes. To date many multitargeted half sandwiched Run-arene complexes were rationally designed by the scientists either by modifying the aromatic unit or altering the chelating ligands that can enhance the selectivity or alter significant biological systems to optimize their chemotherapeutic potential. However, the half sandwiched Run-arene complexes were designed by researchers keeping in mind the use of carrier vehicle HSA since they are relatively scarce in the literature. Hence in this review, we have discussed many examples of drug complexes that interact strongly with HSA which helps in the accumulation of the complexes inside the tumor cells through the EPR (enhanced permeability and retention) effect. Furthermore, the possible mechanisms of action of these half sandwiched Ru-II-arene complexes were also discussed after their selective delivery inside the cancer cells. We hope that multitargeted half sandwiched Ru-II-arene covered in this review will help the researcher's in the future development of new effective organometallic Ru-II drugs using HSA as a platform for the free selective delivery inside tumor cells. (C) 2021 Elsevier B.V. All rights reserved.