Abstract
AIM: The study was designed to evaluate the possible adverse effects and consequences of metal oxide nanoparticles used on some major body organ functions and health parameters.
MATERIALS AND METHODS: Thirty albino rats, allocated randomly into three groups for experimental period of 20 days post-administration were used. Different effects of metal oxide nanoparticles were targeted including, thyroid, parathyroid, kidney, calcium, phosphate, hematological parameters and indices, as well as oxidative stress markers of the red blood cells and their membranes as alpha tocopherol and GSH, by using different analytical methods.
RESULTS: Data revealed thyroid and parathyroid hormonal disturbances; kidney dysfunction in the form of accumulation of some waste products as BUN, creatinine, and uric acid. A decrease in the calcium and phosphate and an increase in the potassium and phosphate concentrations was recorded. A marked decrease in the indices of anemia and diminished oxidative stress indicators were also evident, associated with marked increase in the total leukocyte count.
CONCLUSION: The present study confirmed the health risks of the use of metal oxide nanoparticles in the medical field without precautions and supervision; and may encourage application of nanoparticles from alternative origins, such as plants, algae, or microorganisms instead (Tab. 5, Fig. 4, Ref. 30).