Abstract
Polyzwitterionic biomateria with pH-responsive and henloconipatible dual functions is formulated by the copolymerization of N-dimetnyl amino) ethyl methectylete (DMAEMA) sequences and sulfobetaine methacrylate (SBMA) moieties. Hydrogels are salt responsive, due to the interplay between hydrogen bonds formation, ions solvation, and antipolyelectrolyte effect, while DMAEMA sequences provide pH-responsiveness. Their low-fouling nature is demonstrated using plasma proteins and bacteria. Improved hemocompatibility with SBMA content is unveiled by the resistance to platelet and erythrocyte attachment, as well as from delayed plasma clotting time. Overall, this study suggests that dual-functional zvvitterionic hydrogels are promising pH-responsive and hemocompatible polymeric biomaterials.
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