Abstract
Objectives: To examine laser microdissection and mass spectrometry (LIVID-MS), which has emerged as a new tool to aid in typing amyloid proteins.
Results: ALECT-2 is a potential cause of hepatic amyloidosis best detected by LIVID-MS.
Methods: One of the more recently reported proteins is ALECT-2 (leukocyte cell derived chemotaxin 2) amyloid, found in renal specimens of Hispanic patients. Here we report the first case of hepatic ALECT-2 amyloidosis diagnosed by LMD-MS from a liver biopsy specimen of a 52 year-old Hispanic man and causing portal hypertension with recurrent esophageal variceal bleeding.
Conclusions: ALECT-2 can cause amyloidosis in organs other than the kidneys. It should be strongly considered in Hispanic patients and in those with a globular pattern of amyloid deposition. The incidence of ALECT-2 amyloidosis is likely underreported