Abstract
Imidacloprid is a tobacco related insecticide. It may cause toxicity to rodents and plants pests and other creatures that can pose problems for agriculture. Lipoic acid acts as a potent antioxidant scavenging free radicals. The study aimed to assess biochemical and antioxidant alterations associated with hepatotoxicity. Various biochemical parameters, antioxidant status and comet as well as histopathological examinations were employed to evaluate the protective effect of lipoic acid. Sixty male albino rats were divided into six groups of 10 rats/ group. One group as control, and the other five served as experimental groups passed the treatment for 30 days. The study revealed that exposure to imidacloprid caused a significant alteration in serum biochemical parameters, antioxidant enzymes indicating liver toxicity. Liver DNA damage was indicated as significant changes in comet assay; histopathological degeneration in liver tissue architecture confirmed the above findings. However, lipoic acid supplementation with imidacloprid to rats, manifested significant protective effects. Lipoic acid may have therapeutic potential for use in the prevention of liver injury.