Abstract
Thiazolyl acetonitrile (2) was prepared and converted to pyrazolo[5,1-c][1,2,4]triazine (5), thiazoline-4-one derivatives (10,12), thiazolo[3,2-a]pyridine (13), coumarin (14), and benzo[f]coumarin (16) derivatives through reactions with a variety of organic electrophiles and nucleophiles. Thiazolyl acrylonitrile derivatives (17, 18, 21, 26-28, 31-33) were also prepared, and their activity with a variety of reagents was investigated. The structure of these compounds was elucidated on the basis of elemental analysis, IR,
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H-NMR, and mass spectra. The antimicrobial and antifungal activities of the prepared compounds are also reported.