Abstract
2-Amino-5-[6-(dibenzothien-4-yl)-4,5-dihydropyridazin-3-yloxymethyl]-1,3,4-thiadiazole (2) has been synthesised by treating thiosemicarbazide with the acid 1. The amine (2) on treatment with aromatic aldehydes furnishes schiff bases of thiadiazoles (3a,b) which on reaction with thioglycollic acid yield 4-thiazolidinone derivatives (4a,b). Reaction of 2 with phenyl isocyanate and phenyl isothiocyanate give the corresponding aminocarbamide and aminocarbothiamide derivatives (6 and 7), respectively, which on reaction with malonic acid in acetyl chloride afford baribituric and thiobarbituric acid derivatives (8a,b), respectively. However, reaction of carbon disulphide and methyl iodide with 2 give dithiocarbamidate derivative (9) which on treatment with o-phenylenediamine and ethylenediamine give 10 and 11, respectively.