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Heterocycles [h]fused onto 4-oxoquinolines. Part I. Synthesis of 6-oxo-6,9-dihydro[1,2,5]oxadiazolo[3,4-h]-quinoline-7-carboxylic acid N-oxide
Journal article   Peer reviewed

Heterocycles [h]fused onto 4-oxoquinolines. Part I. Synthesis of 6-oxo-6,9-dihydro[1,2,5]oxadiazolo[3,4-h]-quinoline-7-carboxylic acid N-oxide

Yusuf M. Al-Hiari, Monther A. Khanfar, Ali M. Qaisi, Mohammad Y. Abu Shuheil, Mustafa M. El-Abadelah and Roland Boese
Heterocycles, Vol.68(6), p.1163
01/01/2006
DOI: https://doi.org/10.3987/COM-06-10711

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Ethyl 9-cyclopropyl-4-fluoro-6-oxo-6,9-dihydro[1,2,5]oxadiazolo[3,4-h]quinoline-7-carboxylate N(3)-oxide (3) is synthesized via pyrolysis of the 7-azido-8-nitroquinoline-3-carboxylate precursor (6). Acid-catalyzed hydrolysis of the product (3) afforded the corresponding carboxylic acid (4), of which structures are confirmed by spectroscopic means including X-Ray measurements.

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