Abstract
The reaction of acetamide and malononitrile with elemental sulfur in ethanol containing piperidine catalyst afforded 3-cyano-2,4-diamino thiophene 1, which readily underwent condensation reaction with different aromatic aldehydes to yield Schiff bases (2a-c) Cyclization of (2a-e) by refluxing with chloroacetyl chloride and/or mercaptoacetic acid afforded new (beta-lactam (3a-c) and New thiazolidinone (4a-c) derivatives, respectively. In addition, 1 reacted with chloroacetyl chloride in presence of ethanol and triethylamine to give 6. compound 6 react with different nitroso compounds to give Schiff bases (7a-c) which underwent cyclization with chloroacetyl chloride and/or mercaptoacetic acid to give spiro (beta-lactam (8a-c) and spiro thiazolidinone derivatives (9a-c), respectively. Also, 6 reacts with different aromatic amines in presence of ethanol and piperidine catalyst to give Schiff bases (10a-c), cyclization of (10a-c) with chloroacety1chloride and/or mercaptoacetic acid afforded spiro beta-lactam (11a-c) and Spiro thiazolidine derivatives (12a-c).