Heterogeneous chemo-, regio- and diastereoselective hydrogenation of steroidic alpha-diketone

Valérie Gertosio; Catherine C Santini; Jean Marie Basset; François Bayard; Jean Buendia; Michel Vivat

doi:10.1016/S1381-1169(98)00277-5

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Heterogeneous chemo-, regio- and diastereoselective hydrogenation of steroidic alpha-diketone

Journal article

Peer reviewed

Heterogeneous chemo-, regio- and diastereoselective hydrogenation of steroidic alpha-diketone

Valérie Gertosio, Catherine C Santini, Jean Marie Basset, François Bayard, Jean Buendia and Michel Vivat

Journal of molecular catalysis. A, Chemical, Vol.142(2), pp.141-145

10/06/1999

DOI: https://doi.org/10.1016/S1381-1169(98)00277-5

Abstract

Chemo-, regio-, diastereoselective hydrogenation

Heterogeneous catalysis

Steroid

Supported catalysts, Rh/SiO 2, Ru/SiO 2, Pd/SiO 2, Pt/SiO 2 and Pd/C reduce methyloate of 3α-acetyl-11,12-dioxo-5β-cholan-24-oic acid 1 into the vicinal hydroxyketone 11-oxo,12β-OH 2 in 100% chemo-, regio- and diastereoselectivity at 100% of conversion.

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Title: Heterogeneous chemo-, regio- and diastereoselective hydrogenation of steroidic alpha-diketone
Creators - without role: Valérie Gertosio - École d'Ingénieurs en Chimie et Sciences du Numérique
Catherine C Santini - École d'Ingénieurs en Chimie et Sciences du Numérique
Jean Marie Basset - École d'Ingénieurs en Chimie et Sciences du Numérique
François Bayard - École d'Ingénieurs en Chimie et Sciences du Numérique
Jean Buendia - Hoechst-Marion-Roussel, 111 route de Noisy, 93230 Romainville, France
Michel Vivat - Hoechst-Marion-Roussel, 111 route de Noisy, 93230 Romainville, France
Publication Details: Journal of molecular catalysis. A, Chemical, Vol.142(2), pp.141-145
Publisher: Elsevier B.V
Identifiers: 9941977608331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article