Abstract
A range of hexadentate 3-hydroxypyridin-4-ones have been synthesized. These compounds were found to possess a high affinity for iron(III), with logK1 values of about 34 and pFe values over 30. Antimicrobial assays indicated that they can inhibit the growth of three clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) and three clinical isolates of Pseudomonas, suggesting that hexadentate 3-hydroxypyridin-4-ones have potential application in the treatment of wound infections.
A range of hexadentate 3-hydroxypyridin-4-ones with a high iron(III) affinity have been synthesized. They were found to exhibit a significant inhibitory effect on clinical isolates of MRSA and Pseudomonas strains. [Display omitted]
•A series of novel hexadentate 3-hydroxypyridin-4-one ligands have been synthesized.•These chelators possess a high affinity for iron(III).•Some exhibit a moderate inhibitory effect on MRSA (MIC 384 μg/mL) and Pseudomonas sp. (MIC 256 μg/mL).