High Rates of Prescribing Antimicrobials for Prophylaxis in Children and Neonates: Results From the Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey

Markus Hufnagel; Ann Versporten; Julia Bielicki; Nico Drapier; Mike Sherland; Herman Goossens; Graciela Maria Calle; Julia Clark; Celia Cooper; Christopher C. Blyth; Joshua Reginald Francis; Jameela Alsalman; Hilde Jansen; Ludo Mahieu; Paul Van Rossom; Wouter Vandewal; Philippe Lepage; Sophie Blumental; Caroline Briquet; Dirk Robbrecht; Pierre Maton; Patrick Gabriels; Zana Rubic; Tanja Kovacevic; Jens Peter Nielsen; Jes Reinholdt Petersen; Porntiva Poorisrisak; Lise Heilmann Jensen; Mari Laan; Eda Tamm; Maire Matsinen; Maija-Liisa Rummukainen; Vincent Gajdos; Romain Olivier; Flore Le Marechal; Alain Martinot; Francois Dubos; Marion Lagree; Sonia Prot-Labarthe; Mathie Lorrot; Daniel Orbach; Karaman Pagava; Markus Knuf; Stephanie A. A. Schlag; Johannes Liese; Lorna Renner; Anthony Enimil; Marah Awunyo; Garyfallia Syridou; Nikos Spyridis; Elena Critselis; Sofia Kouni; Katerina Mougkou; Fani Ladomenou; Despoina Gkentzi; Elias Iosifidis; Emmanuel Roilides; Suneeta Sahu; Srinivas Murki; Manoj Malviya; Durga Bhavani Kalavalapalli; Sanjeev Singh; Tanu Singhal; Garima Garg; Pankaj Garg; Neelam Kler; Jafar Soltani; Zahra Jafarpour; Gholamreza Pouladfar; Giangiacomo Nicolini; Carlotta Montagnani; Luisa Galli; Susanna Esposito; Rossana Tenconi; Andrea Lo Vecchio; Daniele Dona; Carlo Giaquinto; Eleonora Borgia; Patrizia D'Argenio; Maia De Luca; Chiara Centenari; Lul Raka; Denis Raka; Abeer Omar; Haifaa Al-Mousa; Dzintars Mozgis; Inese Sviestina; Sigita Burokiene; Vytautas Usonis; Gabriela Tavchioska; Antonia Hargadon-Lowe; Peter Zarb; Michael A. Borg; Carlos Agustin Gonzalez Lozano; Patricia Zarate Castanon; Martha E. Cancino; Bernadette McCullagh; Ann McCorry; Cairine Gormley; Zaina Al Maskari; Amina Al-Jardani; Magdalena Pluta; Fernanda Rodrigues; Ana Brett; Isabel Esteves; Laura Marques; Jameela Ali AlAjmi; Simona Claudia Cambrea; Asia N. Rashed; Aeshah Abdu Mubarak Al Azmi; Si Min Chan; Mas Suhaila Isa; Peter Najdenov; Milan Cizman; Sibila Unuk; Heather Finlayson; Angela Dramowski; Irene Mate-Cano; Beatriz Soto; Cristina Calvo; Begona Santiago; Jesus Saavedra-Lozano; Amaya Bustinza; Luis Escosa-Garcia; Noelia Ureta; Elisa Lopez-Varela; Pablo Rojo; Alfredo Tagarro; Pedro Terol Barrero; Elena Maria Rincon-Lopez; Ismaela Abubakar; Jeff Aston; Mitul Patel; Alison Bedford Russell; Maggie Heginbothom; Prakash Satodia; Mehdi Garbash; Alison Johnson; David Sharpe; Christopher Barton; Esse Menson; Sara Arenas-Lopez; Suzanne Luck; Katja Doerholt; Paddy McMaster; Neil A. Caldwell; Andrew Lunn; Simon B. Drysdale; Rachel Howe; Tim Scorrer; Florian Gahleitner; Richa Gupta; Clare Nash; John Alexander; Mala Raman; Emily Bell; Veena Rajagopal; Stephan Kohlhoff; Elaine Cox; Kristen Nichols; Theoklis Zaoutis; ARPEC Project Grp

doi:10.1093/jpids/piy019

Journal article

High Rates of Prescribing Antimicrobials for Prophylaxis in Children and Neonates: Results From the Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey

Markus Hufnagel, Ann Versporten, Julia Bielicki, Nico Drapier, Mike Sherland, Herman Goossens, Graciela Maria Calle, Julia Clark, Celia Cooper, Christopher C. Blyth, …

Journal of the Pediatric Infectious Diseases Society, Vol.8(2), pp.143-151

11/05/2019

DOI: https://doi.org/10.1093/jpids/piy019

PMID: 29579259

Abstract

Infectious Diseases

Life Sciences & Biomedicine

Pediatrics

Science & Technology

Background. This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used for prophylaxis among pediatric patients hospitalized in 41 countries worldwide. Methods. Using the standardized Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey was conducted at 226 pediatric hospitals in 41 countries from October 1 to November 30, 2012. Results. Overall, 17 693 pediatric patients were surveyed and 36.7% of them received antibiotics (n = 6499). Of 6818 inpatient children, 2242 (32.9%) received at least 1 antimicrobial for prophylactic use. Of 11 899 prescriptions for antimicrobials, 3400 (28.6%) were provided for prophylactic use. Prophylaxis for medical diseases was the indication in 73.4% of cases (2495 of 3400), whereas 26.6% of prescriptions were for surgical diseases (905 of 3400). In approximately half the cases (48.7% [1656 of 3400]), a combination of 2 or more antimicrobials was prescribed. The use of broad-spectrum antibiotics (BSAs), which included tetracyclines, macrolides, lincosamides, and sulfonamides/trimethoprim, was high (51.8% [1761 of 3400]). Broad-spectrum antibiotic use for medical prophylaxis was more common in Asia (risk ratio [RR], 1.322; 95% confidence interval [CI], 1.202-1.653) and more restricted in Australia (RR, 0.619; 95% CI, 0.521-0.736). Prescription of BSA for surgical prophylaxis also varied according to United Nations region. Finally, a high percentage of surgical patients (79.7% [721 of 905]) received their prophylaxis for longer than 1 day. Conclusions. A high proportion of hospitalized children received prophylactic BSAs. This represents a clear target for quality improvement. Collectively speaking, it is critical to reduce total prophylactic prescribing, BSA use, and prolonged prescription.

Metrics

1 Record Views

See more details

Details

Title: High Rates of Prescribing Antimicrobials for Prophylaxis in Children and Neonates: Results From the Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey
Creators - without role: Markus Hufnagel - University Medical Center Freiburg
Ann Versporten - University of Antwerp
Julia Bielicki - St George's Hospital
Nico Drapier - University of Antwerp
Mike Sherland - George Institute for Global Health
Herman Goossens - University of Antwerp
Graciela Maria Calle - Hosp Pediat Juan P Garrahan, Buenos Aires, DF, Argentina
Julia Clark - St George's Hospital
Celia Cooper - Womens & Childrens Hosp, Adelaide, SA, Australia
Christopher C. Blyth - Princess Margaret Hosp Children, Perth, WA, Australia
Joshua Reginald Francis - Princess Margaret Hosp Children, Perth, WA, Australia
Jameela Alsalman - College Station Medical Center
Hilde Jansen - Univ Hosp Antwerp, Antwerp, Belgium
Ludo Mahieu - Univ Hosp Antwerp, Antwerp, Belgium
Paul Van Rossom - Gen Hosp Klina, Brasschaat, Belgium
Wouter Vandewal - AZ Sint Lucas, Brugge, Belgium
Philippe Lepage - Hop Univ Enfants Reine Fabiola, Brussels, Belgium
Sophie Blumental - Hop Univ Enfants Reine Fabiola, Brussels, Belgium
Caroline Briquet - Pontifícia Universidade Católica de São Paulo
Dirk Robbrecht - Damiaan Dicht bij het leven
Pierre Maton - Saint Vincent Health System
Patrick Gabriels - Sint Trudo Ziekenhuis Sint Truiden, St Truiden, Belgium
Zana Rubic - Univ Hosp Ctr Split, Split, Croatia
Tanja Kovacevic - Univ Hosp Ctr Split, Split, Croatia
Jens Peter Nielsen - Regionshosp Viborg, Pediat Dept, Viborg, Denmark
Jes Reinholdt Petersen - University of Copenhagen
Porntiva Poorisrisak - Naestved Hosp, Dept Pediat, Naestved, Denmark
Lise Heilmann Jensen - Roskilde University
Mari Laan - Tallinn Childrens Hosp, Tallinn, Estonia
Eda Tamm - Tartu Univ Hosp, Childrens Clin, Tartu, Estonia
Maire Matsinen - Cent Finland Hlth Care Dist, Jyvaskyla, Finland
Maija-Liisa Rummukainen - Cent Finland Hlth Care Dist, Jyvaskyla, Finland
Vincent Gajdos - University of Paris-Sud
Romain Olivier - University of Paris-Sud
Flore Le Marechal - Univ Hosp, Dept Pediat & Neonatol, Dijon, France
Alain Martinot - Lille Univ Hosp, CHRU Lille, Lille, France
Francois Dubos - Lille Univ Hosp, CHRU Lille, Lille, France
Marion Lagree - Lille Univ Hosp, CHRU Lille, Lille, France
Sonia Prot-Labarthe - Assistance Publique – Hôpitaux de Paris
Mathie Lorrot - Assistance Publique – Hôpitaux de Paris
Daniel Orbach - Institute Curie
Karaman Pagava - College Station Medical Center
Markus Knuf - University Medical Center Freiburg
Stephanie A. A. Schlag - University of Würzburg
Johannes Liese - University of Würzburg
Lorna Renner - Bloomsburg University
Anthony Enimil - Komfo Anokye Teaching Hosp, Kumasi, Ghana
Marah Awunyo - Komfo Anokye Teaching Hosp, Kumasi, Ghana
Garyfallia Syridou - Aglaia Kyriakou Childrens Hosp, Athens, Greece
Nikos Spyridis - Aglaia Kyriakou Childrens Hosp, Athens, Greece
Elena Critselis - Aghia Sophia Childrens Hosp, Univ Dept Pediat 1, Athens, Greece
Sofia Kouni - National and Kapodistrian University of Athens
Katerina Mougkou - National and Kapodistrian University of Athens
Fani Ladomenou - Univ Hosp Heraklion, Iraklion, Greece
Despoina Gkentzi - Univ Gen Hosp Patras, Patras, Greece
Elias Iosifidis - Aristotle University of Thessaloniki
Emmanuel Roilides - Aristotle University of Thessaloniki
Suneeta Sahu - Apollo Hosp, Microbiol, Bhubaneswar, Odisha, India
Srinivas Murki - Fernandez Hosp, Hyderabad, India
Manoj Malviya - Nice Hosp Women Newborns & Children, Hyderabad, India
Durga Bhavani Kalavalapalli - Nice Hosp Women Newborns & Children, Hyderabad, India
Sanjeev Singh - College Station Medical Center
Tanu Singhal - College Station Medical Center
Garima Garg - Escorts Heart Inst, New Delhi, India
Pankaj Garg - Sir Ganga Ram Hosp, New Delhi, India
Neelam Kler - Sir Ganga Ram Hosp, New Delhi, India
Jafar Soltani - College Station Medical Center
Zahra Jafarpour - Shiraz University
Gholamreza Pouladfar - Shiraz University
Giangiacomo Nicolini - San Martino Hosp, Pediat Dept, Belluno, Italy
Carlotta Montagnani - University of Florence
Luisa Galli - University of Florence
Susanna Esposito - University of Milan
Rossana Tenconi - University of Milan
Andrea Lo Vecchio - University of Naples Federico II
Daniele Dona - Dept Woman & Child Hlth, Padua, Italy
Carlo Giaquinto - Dept Woman & Child Hlth, Padua, Italy
Eleonora Borgia - Univ Hosp Padova, Padua, Italy
Patrizia D'Argenio - Bambino Gesu Pediat Hosp, Rome, Italy
Maia De Luca - Bambino Gesu Pediat Hosp, Rome, Italy
Chiara Centenari - Hosp Viareggio, Paediat & Neonatal Unit, Viareggio, Italy
Lul Raka - Natl Inst Publ Hlth Kosovo, Prishtina, Kosovo
Denis Raka - University of Prishtina
Abeer Omar - Minist Hlth, Directorate Infect Control, Kuwait, Kuwait
Haifaa Al-Mousa - Minist Hlth, Directorate Infect Control, Kuwait, Kuwait
Dzintars Mozgis - Riga
Inese Sviestina - Riga
Sigita Burokiene - Vilnius University
Vytautas Usonis - Vilnius University
Gabriela Tavchioska - Gen Hosp Borka Taleski, Prilep, North Macedonia
Antonia Hargadon-Lowe - Queen Elizabeth Cent Hosp, Blantyre, Malawi
Peter Zarb - Mater Dei Hosp, Msida, Malta
Michael A. Borg - Mater Dei Hosp, Msida, Malta
Carlos Agustin Gonzalez Lozano - Inst Nacl Pediat, Mexico City, DF, Mexico
Patricia Zarate Castanon - Inst Nacl Pediat, Mexico City, DF, Mexico
Martha E. Cancino - Univ Autonoma Nayarit, Nayarit, Mexico
Bernadette McCullagh - South Eastern Hlth & Social Care Trust, Belfast, Antrim, North Ireland
Ann McCorry - University of Antwerp
Cairine Gormley - Western Hlth & Social Care Trust, Derry, North Ireland
Zaina Al Maskari - Royal Hosp, Muscat, Oman
Amina Al-Jardani - Royal Hosp, Muscat, Oman
Magdalena Pluta - University of Warsaw
Fernanda Rodrigues - University of Coimbra
Ana Brett - University of Coimbra
Isabel Esteves - Hosp Santa Maria, Pediat Dept, Pediat Infect Dis Unit, Lisbon, Portugal
Laura Marques - Ctr Hosp Porto, Porto, Portugal
Jameela Ali AlAjmi - College Station Medical Center
Simona Claudia Cambrea - Ovidius University
Asia N. Rashed - College Station Medical Center
Aeshah Abdu Mubarak Al Azmi - College Station Medical Center
Si Min Chan - MED Institute
Mas Suhaila Isa - Natl Univ Singapore Hosp, Singapore, Singapore
Peter Najdenov - Gen Hosp Jesenice, Jesenice, Slovenia
Milan Cizman - College Station Medical Center
Sibila Unuk - College Station Medical Center
Heather Finlayson - Stellenbosch University
Angela Dramowski - Tygerberg Hosp, Cape Town, South Africa
Irene Mate-Cano - Hosp Univ Henares, Madrid, Spain
Beatriz Soto - Hosp Univ Getafe, Madrid, Spain
Cristina Calvo - Severn Ochoa Hosp, Madrid, Spain
Begona Santiago - Gregorio Maranon Hosp, Madrid, Spain
Jesus Saavedra-Lozano - Gregorio Maranon Hosp, Madrid, Spain
Amaya Bustinza - Gregorio Maranon Hosp, Madrid, Spain
Luis Escosa-Garcia - Hosp Infantil Univ La Paz, Madrid, Spain
Noelia Ureta - Hosp Univ 12 Octubre, Madrid, Spain
Elisa Lopez-Varela - Hosp Univ 12 Octubre, Madrid, Spain
Pablo Rojo - Hosp Univ 12 Octubre, Madrid, Spain
Alfredo Tagarro - Hosp Univ Infanta Sofia, Madrid, Spain
Pedro Terol Barrero - Hosp Univ Virgen Macarena, Seville, Spain
Elena Maria Rincon-Lopez - Hosp Univ & Politecn La Fe, Valencia, Spain
Ismaela Abubakar - Royal Victoria Teaching Hosp, Edward Francis Small Teaching Hosp, Banjul, Gambia
Jeff Aston - Birmingham Childrens Hosp NHS Fdn Trust, Birmingham, W Midlands, England
Mitul Patel - Birmingham Childrens Hosp NHS Fdn Trust, Birmingham, W Midlands, England
Alison Bedford Russell - Birmingham Childrens Hosp NHS Fdn Trust, Birmingham, W Midlands, England
Maggie Heginbothom - Publ Hlth Wales, Cardiff, S Glam, Wales
Prakash Satodia - Coventry
Mehdi Garbash - Cty Durham & Darlington NHS Fdn Trust, Durham, England
Alison Johnson - Wye Valley NHS Trust
David Sharpe - Alder
Christopher Barton - University of Liverpool
Esse Menson - Evelina London Childrens Hosp, London, England
Sara Arenas-Lopez - Evelina London Childrens Hosp, London, England
Suzanne Luck - Kingston Hosp NHS Fdn Trust, London, England
Katja Doerholt - George Institute for Global Health
Paddy McMaster - North Manchester Gen Hosp, Manchester, Lancs, England
Neil A. Caldwell - Wirral Univ Thaching Hosp NHS Fdn Trust, Wirral, Merseyside, England
Andrew Lunn - Nottingham Childrens Hosp, Nottingham, England
Simon B. Drysdale - University of Oxford
Rachel Howe - Peterborough City Hosp, Peterborough, Cambs, England
Tim Scorrer - Queen Alexandra Hosp, Portsmouth, Hants, England
Florian Gahleitner - Queen Alexandra Hosp, Portsmouth, Hants, England
Richa Gupta - Royal Preston Hosp, Lancashire Teaching Hosp, Preston, Lancs, England
Clare Nash - Sheffield Childrens NHS Fdn Trust, Sheffield, S Yorkshire, England
John Alexander - Univ Hosp North Midlands, Stoke On Trent, Staffs, England
Mala Raman - South Devon Hlth Care NHS Fdn Trust Torquay, Torbay Hosp, Torquay, England
Emily Bell - Royal Cornwall Hosp NHS Trust, Truro, Cornwall, England
Veena Rajagopal - St Georges NHS Trust, London, England
Stephan Kohlhoff - College Station Medical Center
Elaine Cox - IU Hlth, Riley Hosp Children, Indianapolis, IN USA
Kristen Nichols - IU Hlth, Riley Hosp Children, Indianapolis, IN USA
Theoklis Zaoutis - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
ARPEC Project Grp
Publication Details: Journal of the Pediatric Infectious Diseases Society, Vol.8(2), pp.143-151
Publisher: Oxford Univ Press
Number of pages: 9
Grant note: 2009 11 01 / European Commission Directorate General for Health and Consumers (DG Sanco) through the Executive Agency for Health and Consumers Paediatric European Network for Treatment of AIDS
Identifiers: 9921609708331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article