Abstract
Azines derivatives of phenothiazines were synthetically constructed from one-pot multicomponent reactions of 1-(4a,10a-dihydro-10H-phenothiazin-2-yl)ethan-1-one with various reagents. The obtained novel target compounds were evaluated as antioxidant agents using ABTS(+center dot) scavenging assay. Antioxidant results revealed that the incorporation of azines to phenothiazine ring system enhanced the activity. In addition, compound 18 prevent the damage of DNA due to the formation of bleomycin-iron complex more than the standard compound.