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Highly Diastereoselective Peptide Chain Extensions of Unprotected Amino Acids with N-(Z-α-Aminoacyl)benzotriazoles
Journal article   Peer reviewed

Highly Diastereoselective Peptide Chain Extensions of Unprotected Amino Acids with N-(Z-α-Aminoacyl)benzotriazoles

Alan R. Katritzky, Kazuyuki Suzuki and Sandeep K. Singh
Synthesis (Stuttgart), Vol.2004(16), pp.2645-2652
03/11/2004
DOI: https://doi.org/10.1055/s-2004-831255

Abstract

paper
ABSTRACT Coupling an unprotected amino acid or dipeptide in partially aqueous solution with a readily available N-(Z-α-amino­acyl)benzotriazole or N-(Z-α-aminopetidoyl)benzotriazole affords N-terminal-protected di-, tri-, and tetrapeptides in yields of 85-98% (average 95% for 2A-I, 93% for 4A-F and 4A′, 86% for 5A-B) with minimal epimerization.

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