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Highly Enantioselective Co-Catalytic Direct Aldol Reactions by Combination of Hydrogen-Bond Donating and Acyclic Amino Acid Catalysts
Journal article   Peer reviewed

Highly Enantioselective Co-Catalytic Direct Aldol Reactions by Combination of Hydrogen-Bond Donating and Acyclic Amino Acid Catalysts

Guangning Ma, Agnieszka Bartoszewicz, Ismail Ibrahem and Armando Cordova
Advanced synthesis & catalysis, Vol.353(17), pp.3114-3122
11/2011
DOI: https://doi.org/10.1002/adsc.201100408

Abstract

Chemistry Chemistry, Applied Chemistry, Organic Physical Sciences Science & Technology
Highly enantioselective co-catalytic direct aldol reactions by a combination of simple hydrophobic acyclic amino acid and hydrogen-bond donating catalysts are presented. The corresponding aldol products are formed in high yields with high regio-, diastereo-(anti or syn) and enantioselectivity (up to 99.5:0.5 er). The catalyst loadings can be decreased to as little as 2 mol%.

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