Abstract
Novel simple, selective and sensitive poly(vinyl chloride) membrane sensors are developed for the determination of pioglitazone in biological samples (urine) and pharmaceutical preparations. Potentiometric measurements were based on iodobismuthite-drug ion-pair as novel electroactive materials incorporating a plasticized PVC membrane with o-nitrophenyl octyl ether or dioctyl phthalate. Each sensor was conditioned for at least two days in 0.1 M drug solution before use. It exhibited fast and stable Nernstian response for pioglitazone over the concentration range of 1.0x10(-7)-1.0x10(-2) M, pH range of 3.0-7.0 pioglitazone sensors. Results with an average recovery not more than 100.4% and a mean standard deviation less than 1.0% of the nominal were obtained for the two sensors. The sensors showed reasonable selectivity towards investigated drugs in presence of many cations.