Abstract
Sensitive, accurate and precise square-wave voltammetric method was developed and validated for determination of a new antiplatelet drug ticagrelor in drug substance usingmulti-walled carbon nanotubes titanium dioxide nanoparticles modified carbon paste electrode (MWCNTs/TiNPs/CPE). The electrochemical behavior of ticagrelor showed irreversible adsorption-diffusion controlled process at potential of 0.97 V in Britton Robinson buffer (pH 2.0). Various experimental conditions were investigated and optimized including different pH, buffers, electrode modifiers, scan rates and several surfactants. The diffusion coefficient was calculated using chronoamperometric technique. The peak current varied linearly over the concentration ranges from 1.00 x 10(-6) mol L-1 to 1.90 x 10(-4) mol L-1 with correlation coefficients of 0.9992. The detection and quantification limits were 2.81 x 10(-7) and 8.41 x 10(-7) mol L-1, respectively. The method was successfully applied for the determination of ticagrelor in drug product and biological fluid. The pharmacokinetic parameters of drug in human plasma were estimated as: C-max = 1.19 x 10(-6) mol L-1, t(max) = 2 h, CL = 0.0024 Lh(-1) and t(1/2) = 6.5 h which are favorably compared with those reported in literature. (C) 2017 The Electrochemical Society. All rights reserved.