Abstract
The thiazole ring system is one of the most important heterocycles in nature, as it represents an important structural motif of many biological compounds, including vitamin B-1 (Thiamin), carboxylase and penicillin. There is, therefore, an urgent need to design rapid, efficient and environmentally benign protocols for the synthesis of thiazoles. Herein, we have developed a one-pot protocol for the synthesis of 4-aryl-2-aminothiazoles from the reaction of aromatic ketones, NBS (N-Bromosuccinimide) and thioureas under microwave irradiation at 80-85 A degrees C in PEG (polyethylene glycol)-400 and water as a green reaction medium. The products were obtained in 84-89% yields in 28-32 min. The method has several advantages such as use of green solvent, easy work-up, excellent yield and avoiding use of lachrymatric alpha-haloketones.