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Highly enantioselective organocatalytic addition of unmodified aldehydes to N-Boc protected imines: one-pot asymmetric synthesis of beta-amino acids
Journal article   Peer reviewed

Highly enantioselective organocatalytic addition of unmodified aldehydes to N-Boc protected imines: one-pot asymmetric synthesis of beta-amino acids

Jan Vesely, Ramon Rios, Ismail Ibrahem and Armando Cordova
Tetrahedron letters, Vol.48(3), pp.421-425
15/01/2007
DOI: https://doi.org/10.1016/j.tetlet.2006.11.076

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Highly enantio selective catalytic routes to Boc protected beta-amino aldehydes, P-amino acids and gamma-amino alcohols are presented. The organocatalytic asymmetric reactions between unmodified aldehydes and N-Boc protected aryl imines proceed with excellent chemo- and enantioselectivities to give the corresponding compounds in high yields with up to > 19:1 dr and 93% to > 99% ee. (c) 2006 Published by Elsevier Ltd.

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