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Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction
Journal article   Peer reviewed

Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction

Ramon Rios, Henrik Sunden, Ismail Ibrahem, Gui-Ling Zhao, Lars Eriksson and Armando Cordova
Tetrahedron letters, Vol.47(48), pp.8547-8551
27/11/2006
DOI: https://doi.org/10.1016/j.tetlet.2006.09.135

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A highly enantio selective catalytic asymmetric synthesis of 2H-1-benzothiopyrans is presented. The organocatalytic asymmetric domino reactions between 2-mercaptobenzaldehyde and alpha,beta-unsaturated aldehydes proceed with excellent chemoand enantioselectivities to give the corresponding pharmaceutically valuable benzothiopyrans in high yields with 91-98% ee. (c) 2006 Elsevier Ltd. All rights reserved.

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