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Histidine analogues of oxytocin and vasopressin as efficient ligands for Zn2+ ions - Potentiometric and NMR studies
Journal article   Peer reviewed

Histidine analogues of oxytocin and vasopressin as efficient ligands for Zn2+ ions - Potentiometric and NMR studies

Justyna Brasun, Marek Cebrat, Mariusz Jaremko, Lukasz Jaremko, Olimpa Gladysz and Igor Zhukov
Journal of inorganic biochemistry, Vol.103(7), pp.1033-1038
01/07/2009
DOI: https://doi.org/10.1016/j.jinorgbio.2009.04.016
PMID: 19515425

Abstract

Biochemistry & Molecular Biology Chemistry Chemistry, Inorganic & Nuclear Life Sciences & Biomedicine Physical Sciences Science & Technology
We have characterized the interaction between the Zn2+ ions and the histidine analogues of oxytocin and arginine-vasopressin. Potentiometric methods were used for the determination of the stoichiometry of the complexes formed and the calculation of their stability constants. The NMR measurements revealed detailed structures of the complexes and confirmed the binding mode at physiological pH. (C) 2009 Elsevier Inc. All rights reserved.

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