Abstract
Aqueous extract of Myristica fragrans was evaluated for its renal cortical structures of changes of male and female Wistar rats. Rats of both sexes (n = 40) were randomly assigned into two treatment and two Control groups(n=10 each). Groups (G1&G3) served as control, while the rats in the test groups (G2&G4) received oral daily single dose of 1000 mg/kg b.w of aqueous extract nutmeg for 6 weeks. Serum biomarker urea nitrogen, serum creatinine and alkaline phosphatase of kidney injury pointed at levels increased as well as body weights and the mean relative kidney weights were affected by the treatment. Examination histological showed congested and fragmented glomeruli of treated male rats. While, glomerular in the female rats appeared atrophy and tissue lysis. However proximal convoluted tubules appeared atrophy, necrosis, cytoplasmic degeneration with brush border damage and cellular infiltration in male and female treated groups. In addition, destruction of cytoplasmic organelles, irregular of basement membrane with dilation of basal in folding were observed in distal convoluted tubules both treated sexes. The results of the present study suggest that use of nutmeg in higher doses (1000 mg/kg) could be toxic to the renal cortical tissues and metabolic functions in both rats sexes.