Abstract
Background: Artesunate, a potent and rapidly acting blood schizontocide generally used to treat chloroquine resistant malaria. Artesunate has been noted to produced hepatotoxicity, neurotoxicity and hematological abnormalities besides cause embryo, reduced reproductive capacity. Material and Methods: The present study reported sub-chronic safety profile of artesunate on the liver of Wistar rat after 7 days oral administration at 2, 4 and 8 mg kg(-1) day(-1). Results: Treatment with artesunate at 4 and 8 mg kg(-1) day(-1) produced inflammatory changes in liver besides sinusoidal dilation, sinusoidal congestion, cytoplasmic vaculation and focal necrosis. Conclusion: Drugs may yield adverse effects instead of fight against illnesses, when administered inaccurately. It is right time that now all countries should issue proper guidelines. So, it is very important to aware certified drug sellers and medicine store keepers to regularly create awareness in drug users on how to use their prescribed drugs.