Abstract
Background and Objective: Carisoprodol is a musculoskeletal relaxant associated with painful musculoskeletal conditions and there are no adequate studies concerning Carisoprodol effects on fetuses treated maternally with Carisoprodol. This study was conducted to clarify the histopathological, histochemical and immunological changes in fetal pancreas of Albino rats after maternal treatment with high and low doses of Carisoprodol drug (Somadril). Materials and Methods: Thirty adult pregnant rats were used in the present work and categorized into three groups (ten pregnant female rats in every group) first group served as the control group (C). The second and third groups (S1 and S2) were treated with oral doses of Carisoprodol in the distilled water equal to 10.8 and 21.6 mg/100 g, respectively of body weight/day. Groups S1 and S2 were administered for 15 days from day 6 to the 20th days of pregnancy. Pregnant rats were sacrificed on the 20th day of pregnancy and small sections of fetal pancreatic tissue were reserved for histopathological, histochemical and immunological studies. Results: Numerous histopathlogical, histochemical and immunological alternations were detected in the fetal pancreatic tissue of the two groups after maternal treatment with high and low doses of Carisoprodol compared to the control group. Conclusion: The present study showed that administration of Carisoprodol caused several histological, histochemical and immunohistochemical deformity in the fetal pancreatic tissues.