Abstract
The consensus interferons are artificially engineered proteins that combine most of the therapeutic features of natural human alpha-interferons and show high anti-cancer and anti-viral activities. Egyptian patients infected with hepatitis C virus (HCV) genotype 4 show lower responses to interferon (IFN) therapy than the distributed worldwide patients infected with the other HCV genotypes. Numerous studies have reported that patients with hepatitis C who have not responded to a previous standard IFN-alpha therapy or those who relapsed following treatment cessation may benefit from retreatment with consensus IFN-alpha (cIFN-alpha). IFNs-alpha are shown here to have functionally important disordered regions. Furthermore, a strong correlation is established between the peculiarities of disorder profiles of these proteins and their known structural features. Intrinsic disorder profiles of existing cIFNs-alpha possess remarkable similarity to the consensus disorder profile calculated as averaged disorder predispositions of all human IFNs-alpha. If the peculiarities of disorder distribution within the protein sequence are related to protein functionality, then comparison of the disorder profiles of artificial cIFNs (query profiles) with the averaged disorder predisposition profile of human IFNs-alpha (target profile) can be used in the design novel cIFNs. The goal here would be to achieve a close similarity between the query and target profiles by manipulating the cIFN sequence. (C) 2015 Elsevier Ltd. All rights reserved.