Abstract
The presence of hyaline eosinophilic inclusions in protoplasmic astrocytes of cerebral cortex is a rare finding that is mostly associated with history of intractable epilepsy and cases of Aicardi syndrome. Here, we describe a 17-year-old male who presented with a longstanding history of intractable epilepsy. Microscopic examination of the excisional biopsy of the epileptic focus showed hyaline eosinophilic inclusions within cortical astrocytes. In addition, we discuss the most recent evidence with regards to their pathogenesis.