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Hydroamination of terminal alkynes with secondary amines catalyzed by copper: regioselective access to amines
Journal article   Peer reviewed

Hydroamination of terminal alkynes with secondary amines catalyzed by copper: regioselective access to amines

Janet Bahri, Rémi Blieck, Bassem Jamoussi, Marc Taillefer and Florian Monnier
Chemical communications (Cambridge, England), Vol.51(56), pp.11210-11212
30/06/2015
DOI: https://doi.org/10.1039/C5CC02677F
PMID: 26077650

Abstract

Chemical Sciences Organic chemistry
A simple and convenient copper-catalyzed hydroamination of arylacetylenes with secondary amines has been performed giving a simple access to aliphatic amines after reduction of the hydroaminated products (E-enamines). Here we described a mild catalytic system utilizing CuCN precatalyst without any additive ligands in a solvent-free system.

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