Abstract
Two Pt(II) complexes of propylenediamine-N,N '-diacetic acid (H(2)pdda) have been synthesized in which H(2)pdda is bidentate and tetradentate. The two complexes, [Pt(C7H14N2O4)Cl-2] (1) and [Pt(C7H12N2O4)] (2), have been characterized by elemental analysis, IR, mass spectroscopy, and thermal (TGA and DTG) analysis. The crystal structure of 1 and [Pt(C7H12N2O4)]center dot 3H(2)O (2a) are reported. In vitro cytotoxic properties of 1 and 2 were evaluated against HEPG2 (liver carcinoma cell lines) and HCT116 (colon carcinoma cell lines), and were compared with the standard anticancer drugs cisplatin (cis-DDP) and doxorubicin (Dox). The obtained data indicate that the two complexes show weak cytotoxic activity against the two tested cell lines, except for 1 which revealed a relatively high activity against HEPG2. Structure-activity relationships have been interpreted.