Abstract
A case of hypersplenism with sequestration and destruction of granulocytes and platelets in a child with acute lymphocytic leukemia in complete hematologic remission is reported. Splenectomy alleviated this child's problem and enabled chemotherapy to be continued. The absence of any demonstrable cause for the hypersplenism makes this case even more unusual. The problem of 6‐mercaptopurine‐ or methotrexate‐produced liver disease, or post‐irradiation fibrosis with secondary portal hypertension, are alluded to but could not be definitely related to this child's hypersplenism.