Abstract
In the present investigation three lipids namely, compritol 888ATO, compritol E and precirol ATO5 were used for loading the hydrophilic drug dextromethorphane. The aim of this investigation was to find the possibility of the tested lipids to carry a hydrophilic drug and controlling its release. The spray drying technique was applied to produce the lipid loaded dextromethorphan in a microparticles. The results reveald the formation of nearly spherical microparticles with plausible yield and entrapment. DSC and FTIR showed the presence of interaction between dextromethorphan and the tested lipids. The release of drug from the prepared microparticles resulted in expulsion of dextromethorphan from the microparticles of compritol E and precirol ATO5 in a fast rate. However, compritol 888ATO microparticles released the drug mor slowly. It was concluded that compritol 888ATO appear as a promising lipid for sustaining the release of dextromethorphan.