INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells

C Bonner; S Bacon; C G Concannon; S R Rizvi; M Baquié; A M Farrelly; S M Kilbride; H Dussmann; M W Ward; C M Boulanger; C B Wollheim; R Graf; M M Byrne; J H M Prehn

doi:10.5167/uzh-45904

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INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells

Journal article

Peer reviewed

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells

C Bonner, S Bacon, C G Concannon, S R Rizvi, M Baquié, A M Farrelly, S M Kilbride, H Dussmann, M W Ward, C M Boulanger, …

2010

DOI: https://doi.org/10.5167/uzh-45904

Abstract

Clinic for Visceral and Transplantation Surgery

Medicine & health

Our results suggest that apoptosing INS-1 cells shed microparticles that may stimulate PSP/reg induction in neighboring cells, a mechanism that may facilitate the recovery of β-cell mass in HNF1A-MODY.

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Title: INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells
Creators - without role: C Bonner
S Bacon
C G Concannon
S R Rizvi
M Baquié
A M Farrelly
S M Kilbride
H Dussmann
M W Ward
C M Boulanger
C B Wollheim
R Graf
M M Byrne
J H M Prehn
Publisher: American Diabetes Association
Identifiers: 9942027408331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article