Abstract
The charge-transfer complex (CTC) of ciprofloxacin drug (CIP) as a donor with iodine (I-2) as a sigma acceptor has been studied spectrophotometrically in CHCI3. At maximum absorption bands, the stoichiometry of CIP:iodine system was found to be 1:1 ratio according to molar ratio method. The essential spectroscopic data like formation constant (K-CT), molar extinction coefficient (epsilon(CT)), standard free energy (Delta G(o)), oscillator strength (f), transition dipole moment (mu), resonance energy (R-N) and ionization potential (I-D) were estimated. The spectroscopic techniques such as IR, H-1 NMR, mass and UV-vis spectra and elemental analyses (CHN) as well as TG-DTG and DTA investigations were used to characterize the chelating behavior of CIP/iodine charge-transfer complex. The iodine CT interaction was associated with a presence of intermolecular hydrogen bond. The X-ray investigation was carried out to investigate the iodine doping in the synthetic CT complex. (C) 2011 Elsevier B.V. All rights reserved.