Abstract
Acne vulgaris is a disorder of the pilosebaceous follicles commonly occurs in the adolescent. Isotretinoin is used for the treatment of severe acne vulgaris either topically or orally. Most of the effects of isotretinoin are predictable and well described such as dryness of eyes, lips and nasal mucosa. Musculoskeletal side effects such as myalgia, arthralgia, arthritis, and muscle damage are usually mild and myopathy involving pelvic girdle muscles is rarely reported. The following is a case report for one patient presented to our hospital (King Fahad hospital- Alhfuof); with severe myopathy affecting pelvic girdle muscles, after treatment with oral isotretinoin.