Ibrutinib plus Bendamustine and Rituximab in Untreated Mantle-Cell Lymphoma

Michael L. Wang; Wojciech Jurczak; Mats Jerkeman; Judith Trotman; Pier L. Zinzani; David Belada; Carola Boccomini; Ian W. Flinn; Pratyush Giri; Andre Goy; Paul A. Hamlin; Olivier Hermine; José-Ángel Hernández-Rivas; Xiaonan Hong; Seok Jin Kim; David Lewis; Yuko Mishima; Muhit Özcan; Guilherme F. Perini; Christopher Pocock; Yuqin Song; Stephen E. Spurgeon; John M. Storring; Jan Walewski; Jun Zhu; Rui Qin; Todd Henninger; Sanjay Deshpande; Angela Howes; Steven Le Gouill; Martin Dreyling; SHINE Investigators

doi:10.1056/NEJMoa2201817

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Ibrutinib plus Bendamustine and Rituximab in Untreated Mantle-Cell Lymphoma

Journal article

Peer reviewed

Ibrutinib plus Bendamustine and Rituximab in Untreated Mantle-Cell Lymphoma

Michael L. Wang, Wojciech Jurczak, Mats Jerkeman, Judith Trotman, Pier L. Zinzani, David Belada, Carola Boccomini, Ian W. Flinn, Pratyush Giri, Andre Goy, …

The New England journal of medicine, Vol.386(26), pp.2482-2494

30/06/2022

DOI: https://doi.org/10.1056/NEJMoa2201817

PMID: 35657079

Abstract

Hematology

Leukemia

Lymphoma

Oncology

Treatments in Oncology

A trial involving 523 patients with mantle-cell lymphoma randomly assigned patients to receive bendamustine plus rituximab or these drugs plus ibrutinib. At a median follow-up of 7 years, the median progression-free survival with ibrutinib was nearly 81 months, as compared with 53 months without ibrutinib.

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Title: Ibrutinib plus Bendamustine and Rituximab in Untreated Mantle-Cell Lymphoma
Creators - without role: Michael L. Wang - Lund University
Wojciech Jurczak - Lund University
Mats Jerkeman - Lund University
Judith Trotman - Lund University
Pier L. Zinzani - Lund University
David Belada - Lund University
Carola Boccomini - Lund University
Ian W. Flinn - Lund University
Pratyush Giri - Lund University
Andre Goy - Lund University
Paul A. Hamlin - Lund University
Olivier Hermine - Lund University
José-Ángel Hernández-Rivas - Lund University
Xiaonan Hong
Seok Jin Kim - Lund University
David Lewis - Lund University
Yuko Mishima - Lund University
Muhit Özcan - Lund University
Guilherme F. Perini - Lund University
Christopher Pocock - Lund University
Yuqin Song - Lund University
Stephen E. Spurgeon - Lund University
John M. Storring - Lund University
Jan Walewski - Lund University
Jun Zhu - Lund University
Rui Qin - Lund University
Todd Henninger - Lund University
Sanjay Deshpande - Lund University
Angela Howes - Lund University
Steven Le Gouill - Lund University
Martin Dreyling - Lund University
SHINE Investigators
Publication Details: The New England journal of medicine, Vol.386(26), pp.2482-2494
Publisher: Massachusetts Medical Society
Identifiers: 9942298308331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article