Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Lam C. Tsoi; Sarah L. Spain; Jo Knight; Eva Ellinghaus; Philip E. Stuart; Francesca Capon; Jun Ding; Yanming Li; Trilokraj Tejasvi; Johann E. Gudjonsson; Hyun M. Kang; Michael H. Allen; Ross McManus; Giuseppe Novelli; Lena Samuelsson; Joost Schalkwijk; Mona Stahle; A. David Burden; Catherine H. Smith; Michael J. Cork; Xavier Estivill; Anne M. Bowcock; Gerald G. Krueger; Wolfgang Weger; Jane Worthington; Rachid Tazi-Ahnini; Frank O. Nestle; Adrian Hayday; Per Hoffmann; Juliane Winkelmann; Cisca Wijmenga; Cordelia Langford; Sarah Edkins; Robert Andrews; Hannah Blackburn; Amy Strange; Gavin Band; Richard D. Pearson; Damjan Vukcevic; Chris C. A. Spencer; Panos Deloukas; Ulrich Mrowietz; Stefan Schreiber; Stephan Weidinger; Sulev Koks; Kuelli Kingo; Tonu Esko; Andres Metspalu; Henry W. Lim; John J. Voorhees; Michael Weichenthal; H. Erich Wichmann; Vinod Chandran; Cheryl F. Rosen; Proton Rahman; Dafna D. Gladman; Christopher E. M. Griffiths; Andre Reis; Juha Kere; Rajan P. Nair; Andre Franke; Jonathan N. W. N. Barker; Goncalo R. Abecasis; James T. Elder; Richard C. Trembath; Kristina Callis Duffin; Cindy Helms; David Goldgar; Yun Li; Justin Paschall; Mary J. Malloy; Clive R. Pullinger; John P. Kane; Jennifer Gardner; Amy Perlmutter; Andrew Miner; Bing Jian Feng; Ravi Hiremagalore; Robert W. Ike; Enno Christophers; Tilo Henseler; Andreas Ruether; Steven J. Schrodi; Sampath Prahalad; Stephen L. Guthery; Judith Fischer; Wilson Liao; Pui Kwok; Alan Menter; G. Mark Lathrop; C. Wise; Ann B. Begovich; Alexandros Onoufriadis; Michael E. Weale; Angelika Hofer; Wolfgang Salmhofer; Peter Wolf; Kati Kainu; Ulpu Saarialho-Kere; Sari Suomela; Petra Badorf; Ulrike Hueffmeier; Werner Kurrat; Wolfgang Kuester; Jesus Lascorz; Rotraut Moessner; Funda Schuermeier-Horst; Markward Staender; Heiko Traupe; Judith G. M. Bergboer; Martin den Heijer; Peter C. van de Kerkhof; Patrick L. J. M. Zeeuwen; Louise Barnes; Linda E. Campbell; Caitriona Cusack; Ciara Coleman; Judith Conroy; Sean Ennis; Oliver Fitzgerald; Phil Gallagher; Alan D. Irvine; Brian Kirby; Trevor Markham; W. H. Irwin McLean; Joe McPartlin; Sarah F. Rogers; Anthony W. Ryan; Agnieszka Zawirska; Emiliano Giardina; Tiziana Lepre; Carlo Perricone; Gemma Martin-Ezquerra; Ramon M. Pujol; Eva Riveira-Munoz; Annica Inerot; Asa T. Naluai; Lotus Mallbris; Katarina Wolk; Joyce Leman; Anne Barton; Richard B. Warren; Helen S. Young; Isis Ricano-Ponce; Gosia Trynka; Fawnda J. Pellett; Andrew Henschel; Marin Aurand; Bruce Bebo; Christian Gieger; Thomas Illig; Susanne Moebus; Karl-Heinz Joeckel; Raimund Erbe; Peter Donnelly; Leena Peltonen; Jenefer M. Blackwell; Elvira Bramon; Matthew A. Brown; Juan P. Casas; Aiden Corvin; Nicholas Craddock; Audrey Duncanson; Janusz Jankowski; Hugh S. Markus; Christopher G. Mathew; Mark I. McCarthy; Colin N. A. Palmer; Robert Plomin; Anna Rautanen; Stephen J. Sawcer; Nilesh Samani; Ananth C. Viswanathan; Nicholas W. Wood; Celine Bellenguez; Colin Freeman; Garrett Hellenthal; Eleni Giannoulatou; Matti Pirinen; Zhan Su; Sarah E. Hunt; Rhian Gwilliam; Suzannah J. Bumpstead; Serge Dronov; Matthew Gillman; Emma Gray; Naomi Hammond; Alagurevathi Jayakumar; Owen T. McCann; Jennifer Liddle; Marc L. Perez; Simon C. Potter; Radhi Ravindrarajah; Michelle Ricketts; Matthew Waller; Paul Weston; Sara Widaa; Pamela Whittaker; Collaborative Assoc Study Psoriasi

doi:10.1038/ng.2467

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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Journal article

Peer reviewed

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Lam C. Tsoi, Sarah L. Spain, Jo Knight, Eva Ellinghaus, Philip E. Stuart, Francesca Capon, Jun Ding, Yanming Li, Trilokraj Tejasvi, Johann E. Gudjonsson, …

Nature genetics, Vol.44(12), pp.1341-1348

01/12/2012

DOI: https://doi.org/10.1038/ng.2467

PMID: 23143594

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TA GAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-kappa B signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.

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Title: Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Creators - without role: Lam C. Tsoi - Biostat
Sarah L. Spain - College Station Medical Center
Jo Knight - Ctr Addict & Mental Hlth, Toronto, ON, Canada
Eva Ellinghaus - Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
Philip E. Stuart - Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
Francesca Capon - College Station Medical Center
Jun Ding - Biostat
Yanming Li - Biostat
Trilokraj Tejasvi - Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
Johann E. Gudjonsson - Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
Hyun M. Kang - Biostat
Michael H. Allen - College Station Medical Center
Ross McManus - College Station Medical Center
Giuseppe Novelli - Natl Agcy Evaluat Univ & Res Inst ANVUR, Rome, Italy
Lena Samuelsson - University of Gothenburg
Joost Schalkwijk - Radboud University Nijmegen
Mona Stahle - Karolinska Institutet
A. David Burden - University of Glasgow
Catherine H. Smith - Kings Coll London, St Johns Inst Dermatol, London WC2R 2LS, England
Michael J. Cork - University of Sheffield
Xavier Estivill - CRG, Genes & Dis Programme, Barcelona, Spain
Anne M. Bowcock - Supreme Council Of Health
Gerald G. Krueger - University of Utah
Wolfgang Weger - University of Graz
Jane Worthington - University of Manchester
Rachid Tazi-Ahnini - University of Sheffield
Frank O. Nestle - College Station Medical Center
Adrian Hayday - Kings Coll London, Div Immunol Infect & Inflammatory Dis, London WC2R 2LS, England
Per Hoffmann - University of Bonn
Juliane Winkelmann - Tech Univ Munich, Dept Neurol, Munich, Germany
Cisca Wijmenga - College Station Medical Center
Cordelia Langford - Wellcome Sanger Institute
Sarah Edkins - Wellcome Sanger Institute
Robert Andrews - Wellcome Sanger Institute
Hannah Blackburn - Wellcome Sanger Institute
Amy Strange - Wellcome Trust
Gavin Band - Wellcome Trust
Richard D. Pearson - Wellcome Trust
Damjan Vukcevic - Wellcome Trust
Chris C. A. Spencer - Wellcome Trust
Panos Deloukas - Wellcome Sanger Institute
Ulrich Mrowietz - Univ Kiel, Dept Dermatol, Univ Hosp, D-2300 Kiel, Germany
Stefan Schreiber - Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
Stephan Weidinger - Univ Kiel, Dept Dermatol, Univ Hosp, D-2300 Kiel, Germany
Sulev Koks - University of Tartu
Kuelli Kingo - University of Tartu
Tonu Esko - University of Tartu
Andres Metspalu - University of Tartu
Henry W. Lim - Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA
John J. Voorhees - Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
Michael Weichenthal - Univ Kiel, Dept Dermatol, Univ Hosp, D-2300 Kiel, Germany
H. Erich Wichmann - German Res Ctr Environm Hlth, Helmholtz Zentrum Munich, Inst Epidemiol 1, Neuherberg, Germany
Vinod Chandran - University of Toronto
Cheryl F. Rosen - University of Toronto
Proton Rahman - Mécanique et Engrenage Moderne
Dafna D. Gladman - University of Toronto
Christopher E. M. Griffiths - University of Manchester
Andre Reis - Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany
Juha Kere - Karolinska Institutet
Rajan P. Nair - Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
Andre Franke - Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
Jonathan N. W. N. Barker - College Station Medical Center
Goncalo R. Abecasis - Biostat
James T. Elder - Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
Richard C. Trembath - College Station Medical Center
Kristina Callis Duffin - University of Utah
Cindy Helms - Supreme Council Of Health
David Goldgar - University of Utah
Yun Li - Biostat
Justin Paschall - College Station Medical Center
Mary J. Malloy - Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
Clive R. Pullinger - Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
John P. Kane - Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
Jennifer Gardner - Supreme Council Of Health
Amy Perlmutter - Supreme Council Of Health
Andrew Miner - Supreme Council Of Health
Bing Jian Feng - University of Utah
Ravi Hiremagalore - Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
Robert W. Ike - Supreme Council Of Health
Enno Christophers - Univ Kiel, Dept Dermatol, Univ Hosp, D-2300 Kiel, Germany
Tilo Henseler - Univ Kiel, Dept Dermatol, Univ Hosp, D-2300 Kiel, Germany
Andreas Ruether - Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
Steven J. Schrodi - Celera, Alameda, CA USA
Sampath Prahalad - University of Utah
Stephen L. Guthery - University of Utah
Judith Fischer - Evry
Wilson Liao - Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Pui Kwok - Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Alan Menter - Baylor University
G. Mark Lathrop - Evry
C. Wise - Scottish Rite Freemasonry
Ann B. Begovich - Celera, Alameda, CA USA
Alexandros Onoufriadis - College Station Medical Center
Michael E. Weale - College Station Medical Center
Angelika Hofer - University of Graz
Wolfgang Salmhofer - University of Graz
Peter Wolf - University of Graz
Kati Kainu - University of Helsinki
Ulpu Saarialho-Kere - University of Helsinki
Sari Suomela - University of Helsinki
Petra Badorf - Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany
Ulrike Hueffmeier - Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany
Werner Kurrat - Asklepios Nordseeklin, Westerland Sylt, Germany
Wolfgang Kuester - TOMESA Clin, Bad Salzschlirf, Germany
Jesus Lascorz - Heidelberg
Rotraut Moessner - University of Göttingen
Funda Schuermeier-Horst - University of Münster
Markward Staender - Psoriasis Rehabil Hosp, Bad Bentheim, Germany
Heiko Traupe - University of Münster
Judith G. M. Bergboer - Radboud University Nijmegen
Martin den Heijer - Radboud University Nijmegen
Peter C. van de Kerkhof - Radboud University Nijmegen
Patrick L. J. M. Zeeuwen - Radboud University Nijmegen
Louise Barnes - College Station Medical Center
Linda E. Campbell - University of Dundee
Caitriona Cusack - Univ Coll Hosp Galway, Dept Dermatol, Galway, Ireland
Ciara Coleman - College Station Medical Center
Judith Conroy - College Station Medical Center
Sean Ennis - College Station Medical Center
Oliver Fitzgerald - St Vincents Univ Hosp, Dept Dermatol, Dublin 4, Ireland
Phil Gallagher - St Vincents Univ Hosp, Dept Dermatol, Dublin 4, Ireland
Alan D. Irvine - College Station Medical Center
Brian Kirby - St Vincents Univ Hosp, Dept Dermatol, Dublin 4, Ireland
Trevor Markham - Univ Coll Hosp Galway, Dept Dermatol, Galway, Ireland
W. H. Irwin McLean - University of Dundee
Joe McPartlin - College Station Medical Center
Sarah F. Rogers - St Vincents Univ Hosp, Dept Dermatol, Dublin 4, Ireland
Anthony W. Ryan - College Station Medical Center
Agnieszka Zawirska - St Vincents Univ Hosp, Dept Dermatol, Dublin 4, Ireland
Emiliano Giardina - Natl Agcy Evaluat Univ & Res Inst ANVUR, Rome, Italy
Tiziana Lepre - Natl Agcy Evaluat Univ & Res Inst ANVUR, Rome, Italy
Carlo Perricone - Natl Agcy Evaluat Univ & Res Inst ANVUR, Rome, Italy
Gemma Martin-Ezquerra - Hosp Mar, IMAS, Dermatol Serv, Barcelona, Spain
Ramon M. Pujol - Hosp Mar, IMAS, Dermatol Serv, Barcelona, Spain
Eva Riveira-Munoz - CRG, Genes & Dis Programme, Barcelona, Spain
Annica Inerot - Sahlgrens Univ Hosp, Dept Dermatol & Venerol, Gothenburg, Sweden
Asa T. Naluai - University of Gothenburg
Lotus Mallbris - Karolinska Institutet
Katarina Wolk - Karolinska Institutet
Joyce Leman - University of Glasgow
Anne Barton - University of Manchester
Richard B. Warren - University of Manchester
Helen S. Young - University of Manchester
Isis Ricano-Ponce - College Station Medical Center
Gosia Trynka - College Station Medical Center
Fawnda J. Pellett - University of Toronto
Andrew Henschel - Natl Psoriasis Fdn, Portland, OR USA
Marin Aurand - Natl Psoriasis Fdn, Portland, OR USA
Bruce Bebo - Natl Psoriasis Fdn, Portland, OR USA
Christian Gieger - German Res Ctr Environm Hlth, Helmholtz Zentrum Munich, Inst Genet Epidemiol, Neuherberg, Germany
Thomas Illig - German Res Ctr Environm Hlth, Helmholtz Zentrum Munich, Res Unit Mol Epidemiol, Neuherberg, Germany
Susanne Moebus - University of Duisburg-Essen
Karl-Heinz Joeckel - University of Duisburg-Essen
Raimund Erbe - University of Duisburg-Essen
Peter Donnelly - Wellcome Trust
Leena Peltonen - Wellcome Sanger Institute
Jenefer M. Blackwell - University of Western Australia
Elvira Bramon - College Station Medical Center
Matthew A. Brown - University of Queensland
Juan P. Casas - University of London
Aiden Corvin - College Station Medical Center
Nicholas Craddock - Cardiff University
Audrey Duncanson - Wellcome Trust
Janusz Jankowski - Supreme Council Of Health
Hugh S. Markus - University of London
Christopher G. Mathew - College Station Medical Center
Mark I. McCarthy - Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab ICDEM, Oxford OX3 7LJ, England
Colin N. A. Palmer - University of Dundee
Robert Plomin - Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England
Anna Rautanen - Wellcome Trust
Stephen J. Sawcer - University of Cambridge
Nilesh Samani - University of Leicester
Ananth C. Viswanathan - Moorfields Eye Hosp NHS Fdn Trust, Glaucoma Res Unit, London, England
Nicholas W. Wood - Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England
Celine Bellenguez - Wellcome Trust
Colin Freeman - Wellcome Trust
Garrett Hellenthal - Wellcome Trust
Eleni Giannoulatou - Wellcome Trust
Matti Pirinen - Wellcome Trust
Zhan Su - Wellcome Trust
Sarah E. Hunt - Wellcome Sanger Institute
Rhian Gwilliam - Wellcome Sanger Institute
Suzannah J. Bumpstead - Wellcome Sanger Institute
Serge Dronov - Wellcome Sanger Institute
Matthew Gillman - Wellcome Sanger Institute
Emma Gray - Wellcome Sanger Institute
Naomi Hammond - Wellcome Sanger Institute
Alagurevathi Jayakumar - Wellcome Sanger Institute
Owen T. McCann - Wellcome Sanger Institute
Jennifer Liddle - Wellcome Sanger Institute
Marc L. Perez - Wellcome Sanger Institute
Simon C. Potter - Wellcome Sanger Institute
Radhi Ravindrarajah - Wellcome Sanger Institute
Michelle Ricketts - Wellcome Sanger Institute
Matthew Waller - Wellcome Sanger Institute
Paul Weston - Wellcome Sanger Institute
Sara Widaa - Wellcome Sanger Institute
Pamela Whittaker - Wellcome Sanger Institute
Collaborative Assoc Study Psoriasi
Publication Details: Nature genetics, Vol.44(12), pp.1341-1348
Publisher: Springer Nature
Number of pages: 8
Grant note: U01HG006513 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) G0000934 / UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 068545/Z/02 / Wellcome Trust; European Commission UK National Blood Service controls Welcome Trust; Wellcome Trust Barbara and Neal Henschel Charitable Foundation R01AR050266 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) Health Research Board NF-SI-0507-10379 / National Institute for Health Research; National Institute for Health Research (NIHR) G0601387 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) ZIAAG000693 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) G0601387 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission
Identifiers: 9937285608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article