Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH

Qosay Al-Balas; Nahoum G. Anthony; Bilal Al-Jaidi; Amani Alnimr; Grainne Abbott; Alistair K. Brown; Rebecca C. Taylor; Gurdyal S. Besra; Timothy D. McHugh; Stephen H. Gillespie; Blair F. Johnston; Simon P. Mackay; Geoffrey D. Coxon

doi:10.1371/journal.pone.0005617

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Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH

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Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH

Qosay Al-Balas, Nahoum G. Anthony, Bilal Al-Jaidi, Amani Alnimr, Grainne Abbott, Alistair K. Brown, Rebecca C. Taylor, Gurdyal S. Besra, Timothy D. McHugh, Stephen H. Gillespie, …

PloS one, Vol.4(5), pp.e5617-e5617

19/05/2009

DOI: https://doi.org/10.1371/journal.pone.0005617

PMCID: PMC2680598

PMID: 19440303

Abstract

Antimicrobials and Drug Resistance

Bacterial Infections

Biocatalysis

Chemical Biology

Chemical Biology of the Cell

Chemistry

HIV Infection and AIDS

Infectious Diseases

Neglected Tropical Diseases

Organic Chemistry

Small Molecule Chemistry

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Title: Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH
Creators - without role: Qosay Al-Balas - University of Strathclyde
Nahoum G. Anthony - University of Strathclyde
Bilal Al-Jaidi - University of Strathclyde
Amani Alnimr - University College London
Grainne Abbott - University of Sydney
Alistair K. Brown - University of Sydney
Rebecca C. Taylor - University of Birmingham
Gurdyal S. Besra - University of Birmingham
Timothy D. McHugh - University College London
Stephen H. Gillespie - University College London
Blair F. Johnston - University of Strathclyde
Simon P. Mackay - University of Strathclyde
Geoffrey D. Coxon - University of Strathclyde
Publication Details: PloS one, Vol.4(5), pp.e5617-e5617
Publisher: Public Library of Science
Identifiers: 9915357808331
Academic Unit: Imam Abdulrahman Bin Faisal University
Language: English
Resource Type: Journal article