Abstract
Synthesis of seven new indolenyl sulfonamides, have been prepared by the condensation reaction of indole-3-carboxaldehyde with different sulfonamides such as, sulphanilamide, sulfaguanidine, sulfathiazole, sulfamethoxazole, sulfisoxazole, sulfadiazine and sulfamethazine. These synthesized compounds have been used as potential ligands for complexation with some selective divalent transition metal ions (cobalt, copper, nickel & zinc). Structure of the synthesized ligands has been deduced from their physical, analytical (elemental analyses) and spectral (IR,
1H NMR and
13C NMR & UV–vis) data. All the compounds have also been assayed for their
in vitro antibacterial and antifungal activities examining six species of pathogenic bacteria (
Escherichia coli,
Shigella flexneri,
Pseudomonas aeruginosa,
Salmonella typhi,
Staphylococcus aureus and
Bacillus subtilis) and six of fungi (
Trichophyton longifusus,
Candida albicans,
Aspergillus flavus,
Microsporum canis,
Fusarium soloni and
Candida glabrata). Antibacterial and antifungal results showed that all the compounds showed significant antibacterial activity whereas most of the compounds displayed good antifungal activity. Brine shrimp bioassay was also carried out for
in vitro cytotoxic properties against
Artemia salina.
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