Abstract
A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The
in vitro
anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibit significant inhibition against
Mycobacterium tuberculosis
H37Rv strain with MIC in the range of 1.56–12.5 µg ml
−1
. Noticeably, compound
6s
was the most potent compound
in vitro
with a MIC value of 1.56 µg ml
−1
. Molecular docking and chemoinformatics studies revealed that compound
6s
displayed drug-like properties against the enoyl-acyl carrier protein reductase of
M. tuberculosis
further establishing its potential as a potent inhibitor.