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Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates
Journal article   Peer reviewed

Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates

Alasdair I McKay, Weam A O Altalhi, Lachlan E McInnes, Milena L Czyz, Allan J Canty, Paul S Donnelly and Richard A J O'Hair
Journal of organic chemistry, Vol.85(4), pp.2680-2687
21/02/2020
DOI: https://doi.org/10.1021/acs.joc.9b02831
PMID: 31971390

Abstract

The Ru(II)-catalyzed amidation of 2-arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described previously, due to the formation of a series of side products, which were readily identified using direct infusion electrospray mass spectrometry and high-performance liquid chromatography-mass spectrometry.

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