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Imidazolium ylide mediated tandem Knoevenagel-Michael-O-cyclization sequence for the synthesis of multi-substituted 4,5-dihydrofurans
Journal article   Peer reviewed

Imidazolium ylide mediated tandem Knoevenagel-Michael-O-cyclization sequence for the synthesis of multi-substituted 4,5-dihydrofurans

Sivakumar Sathiyamoorthi, Abdulrahman I. Almansour, Suresh Kumar Raju, Arumugam Natarajan and Raju Ranjith Kumar
Synthetic communications, Vol.51(2), pp.234-244
17/01/2021
DOI: https://doi.org/10.1080/00397911.2020.1821226

Abstract

45-dihydrofuran Aroylacetonitrile imidazolium ylide Knoevenagel reaction tandem reaction
The stereoselective syntheses of novel trans-5-aroyl-2,4-diaryl-4,5-dihydrofuran-3-carbonitriles have been achieved via a one-pot, three-component tandem protocol involving aroyl acetonitriles, aromatic aldehydes, and imidazolium ylide in the presence of Et 3 N.

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