Abstract
The aim of the current research was to evaluate the immunomodulatory potential of methanol extract of
Aegle marmelos
in an experimental animal model of cellular and humoral immunity. Administration of methanol extract of
Aegle marmelos
(500 and 1000 mg/kg,
p.o
.) and
Ocimum sanctum
(100 mg/kg, p.o.), produced significant increase in adhesion of neutrophils and an increase in phagocytic index in carbon clearance assay. Both doses of
Aegle marmelos
prevented the mortality induced by bovine
Pasteurella multocida
in mice. Moreover, all treated groups demonstrated significant elevation in circulating antibody titre in the indirect haemagglunation test. From the above results, it can be concluded that methanol extract of
Aegle marmelos
possess immunomodulatory potential by stimulating cellular and humoral immune mechanisms. However, low dose of methanol extract of
Aegle marmelos
was more effective for augmenting cellular immunity, whereas, high dose was more inclined towards humoral immunity.