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Impact of MCT1 Haploinsufficiency on the Mouse Retina
Journal article   Peer reviewed

Impact of MCT1 Haploinsufficiency on the Mouse Retina

Neal S. Peachey, Minzhong Yu, John Y. S. Han, Sylvain Lengacher, Pierre J. Magistretti, Luc Pellerin and Nancy J. Philp
RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY, Vol.1074, pp.375-380
Advances in Experimental Medicine and Biology
01/01/2018
DOI: https://doi.org/10.1007/978-3-319-75402-4_46
PMCID: PMC6708593
PMID: 29721966

Abstract

Cell Biology Life Sciences & Biomedicine Medicine, Research & Experimental Ophthalmology Research & Experimental Medicine Science & Technology
The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/- heterozygotes, which express half of the normal complement of MCT1. The MCT1(+/-) retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

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