Abstract
Adverse effect of the chronic anabolic androgenic steroid (AAS) exposure on liver tissue and function of adult male albino rats were evaluated. Total 48 adult male albino rats were divided into four groups; (G1) controls, (G2) therapeutic (5 mg/Kg b.w), (G3) low dose (0.9 mg/Kg b.w), (G4) high dose (18 mg/Kg b.w), rats were treated orally with anabol for 3 months. Blood samples were taken from all rats once a month, half of the animals in each group were sacrificed, and organs were dissected for the histopathological examination. Results showed that elevation in plasma liver biomarkers alaninaminotransferase (ALT) aspartateaminotransferase (AST), total proteins and albumin was recorded. Enhancement in superoxide dismutase (SOD) and catalase. Reduction in total reduced glutathione (GSH) concomitant with elevation in lipid peroxidation biomarker (MDA). Histopathological findings encountered changes in the liver architecture. Stop giving anabol in recovery period drawback these findings. Chronic administration of high dose of anabol induced serious injury in liver tissue and remarkable changes in liver biomarkers. Liver recovery needs long time to nearly reach to normal after the chronic exposure to androgenic steroids.