Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis

Stella G. Muthuri; Sudhir Venkatesan; Puja R. Myles; Jo Leonardi-Bee; Wei Shen Lim; Abdullah Al Mamun; Ashish P. Anovadiya; Wildo N. Araujo; Eduardo Azziz-Baumgartner; Clarisa Baez; Carlos Bantar; Mazen M. Barhoush; Matteo Bassetti; Bojana Beovic; Roland Bingisser; Isabelle Bonmarin; Victor H. Borja-Aburto; Bin Cao; Jordi Carratala; Maria R. Cuezzo; Justin T. Denholm; Samuel R. Dominguez; Pericles A. D. Duarte; Gal Dubnov-Raz; Marcela Echavarria; Sergio Fanella; James Fraser; Zhancheng Gao; Patrick Gerardin; Maddalena Giannella; Sophie Gubbels; Jethro Herberg; Anjarath L. Higuera Iglesias; Peter H. Hoeger; Matthias Hoffmann; Xiaoyun Hu; Quazi T. Islam; Mirela F. Jimenez; Amr Kandeel; Gerben Keijzers; Hossein Khalili; Gulam Khandaker; Marian Knight; Gabriela Kusznierz; Ilija Kuzman; Arthur M. C. Kwan; Idriss Lahlou Amine; Eduard Langenegger; Kamran B. Lankarani; Yee-Sin Leo; Rita Linko; Pei Liu; Faris Madanat; Toshie Manabe; Elga Mayo-Montero; Allison McGeer; Ziad A. Memish; Gokhan Metan; Dragan Mikic; Kristin G. I. Mohn; Ahmadreza Moradi; Pagbajabyn Nymadawa; Bulent Ozbay; Mehpare Ozkan; Dhruv Parekh; Mical Paul; Wolfgang Poeppl; Fernando P. Polack; Barbara A. Rath; Alejandro H. Rodriguez; Marilda M. Siqueira; Joanna Skret-Magierlo; Ewa Talarek; Julian W. Tang; Antoni Torres; Selda H. Torun; Dat Tran; Timothy M. Uyeki; Annelies van Zwol; Wendy Vaudry; Daiva Velyvyte; Tjasa Vidmar; Paul Zarogoulidis; Jonathan S. Nguyen-Van-Tam; PRIDE Consortium Investigators

doi:10.1111/irv.12363

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Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis

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Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis

Stella G. Muthuri, Sudhir Venkatesan, Puja R. Myles, Jo Leonardi-Bee, Wei Shen Lim, Abdullah Al Mamun, Ashish P. Anovadiya, Wildo N. Araujo, Eduardo Azziz-Baumgartner, Clarisa Baez, …

Influenza and other respiratory viruses, Vol.10(3), pp.192-204

05/2016

DOI: https://doi.org/10.1111/irv.12363

PMID: 26602067

Abstract

Infectious Diseases

Life Sciences & Biomedicine

Science & Technology

Virology

BackgroundThe impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. MethodsA worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) pandemic influenza'. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. ResultsOf 20 634 included participants, 5978 (290%) had IRP; conversely, 3349 (162%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 083 (95% CI 064-106; P = 0136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 072 (044-117; P = 0180)] or likelihood of requiring ventilatory support [adj. OR = 117 (071-192; P = 0537)], but early treatment versus later significantly reduced mortality [adj. OR = 070 (055-088; P = 0003)] and likelihood of requiring ventilatory support [adj. OR = 068 (054-085; P = 0001)]. ConclusionsEarly NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.

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Title: Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis
Creators - without role: Stella G. Muthuri - University of Nottingham
Sudhir Venkatesan - University of Nottingham
Puja R. Myles - University of Nottingham
Jo Leonardi-Bee - University of Nottingham
Wei Shen Lim - College Station Medical Center
Abdullah Al Mamun - Res Bangladesh ICDDRB, Int Ctr Diarrhoeal Dis, Dhaka, Bangladesh
Ashish P. Anovadiya - College Station Medical Center
Wildo N. Araujo - Universidade de Brasília
Eduardo Azziz-Baumgartner - Ctr Dis Control & Prevent, Atlanta, GA USA
Clarisa Baez - Minist Salud Prov Buenos Aires, Buenos Aires, DF, Argentina
Carlos Bantar - Hosp San Martin Parana, Dept Infect Control, Entre Rios, Argentina
Mazen M. Barhoush - College Station Medical Center
Matteo Bassetti - Santa Maria Misericordia Hosp, Udine, Italy
Bojana Beovic - College Station Medical Center
Roland Bingisser - University of Basel
Isabelle Bonmarin - Inst Veille Sanitaire, St Maurice, France
Victor H. Borja-Aburto - IMSS, Mexico City, DF, Mexico
Bin Cao - College Station Medical Center
Jordi Carratala - Universitat de Barcelona
Maria R. Cuezzo - Minist Salud Tucuman, San Miguel De Tucuman, Argentina
Justin T. Denholm - Peter Doherty Institute
Samuel R. Dominguez - Supreme Council Of Health
Pericles A. D. Duarte - Univ Estadual Oeste Parana, UNIOESTE, Cascavel, PR, Brazil
Gal Dubnov-Raz - College Station Medical Center
Marcela Echavarria - CEMIC Univ Hosp, Clin Virol Lab, Buenos Aires, DF, Argentina
Sergio Fanella - University of Manitoba
James Fraser - Intens
Zhancheng Gao - Peking University
Patrick Gerardin - CHU St Pierre, PFME, NICU PICU, St Pierre, La Reunion, France
Maddalena Giannella - Hosp Gen Univ Gregorio Maranon, Dept Clin Microbiol & Infect Dis, Madrid, Spain
Sophie Gubbels - Veterinary Biological and Research Institute
Jethro Herberg - University of London
Anjarath L. Higuera Iglesias - Inst Nacl Enfermedades Resp, Epidemiol Res Unit, Mexico City, DF, Mexico
Peter H. Hoeger - Cath Childrens Hosp Wilhelmstift, Hamburg, Germany
Matthias Hoffmann - Kantonsspital, Div Infect Dis & Hosp Epidemiol, St Gallen, Switzerland
Xiaoyun Hu - College Station Medical Center
Quazi T. Islam - College Station Medical Center
Mirela F. Jimenez - College Station Medical Center
Amr Kandeel - Minist Hlth Egypt, Cairo, Egypt
Gerben Keijzers - Gold Coast Hosp, Gold Coast, Qld, Australia
Hossein Khalili - University of Tehran
Gulam Khandaker - University of Sydney
Marian Knight - University of Oxford
Gabriela Kusznierz - Natl Inst Resp Dis Emilio Coni ANLIS C Malbran, Santa Fe, NM, Argentina
Ilija Kuzman - University of Zagreb
Arthur M. C. Kwan - Intens
Idriss Lahlou Amine - Level
Eduard Langenegger - Stellenbosch University
Kamran B. Lankarani - Shiraz University
Yee-Sin Leo - Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore
Rita Linko - Helsinki Univ Hosp, Helsinki, Finland
Pei Liu - College Station Medical Center
Faris Madanat - King Hussein Canc Ctr, Dept Pediat, Amman, Jordan
Toshie Manabe - University of Tsukuba
Elga Mayo-Montero - College Station Medical Center
Allison McGeer - University of Toronto
Ziad A. Memish - Minist Hlth, Riyadh, Saudi Arabia
Gokhan Metan - Erciyes University
Dragan Mikic - College Station Medical Center
Kristin G. I. Mohn - College Station Medical Center
Ahmadreza Moradi - Johns Hopkins University
Pagbajabyn Nymadawa - Minist Hlth, Natl Ctr Communicable Dis, Natl Influenza Ctr, Ulaanbaatar, Mongolia
Bulent Ozbay - College Station Medical Center
Mehpare Ozkan - Ankara
Dhruv Parekh - University of Birmingham
Mical Paul - Rambam Hlth Care Campus, Div Infect Dis, Haifa, Israel
Wolfgang Poeppl - University of Vienna
Fernando P. Polack - Vanderbilt University
Barbara A. Rath - Charité - Universitätsmedizin Berlin
Alejandro H. Rodriguez - Hosp Joan 23, CIBERES, URV, IISPV,Critical Care Dept, Tarragona, Spain
Marilda M. Siqueira - Fiocruz MS, Inst Oswaldo Cruz, Lab Resp Viruses, BR-21045900 Rio De Janeiro, Brazil
Joanna Skret-Magierlo - Uniwersytet Rzeszowski, Rzeszow, Poland
Ewa Talarek - University of Warsaw
Julian W. Tang - College Station Medical Center
Antoni Torres - Universitat de Barcelona
Selda H. Torun - College Station Medical Center
Dat Tran - University of Toronto
Timothy M. Uyeki - Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA USA
Annelies van Zwol - University of Amsterdam
Wendy Vaudry - University of Alberta
Daiva Velyvyte - Lithuanian Univ Hlth Sci, Kaunas, Lithuania
Tjasa Vidmar - Gen Hosp, Slovenj Gradec, Slovenia
Paul Zarogoulidis - Democritus University of Thrace
Jonathan S. Nguyen-Van-Tam - University of Nottingham
PRIDE Consortium Investigators
Publication Details: Influenza and other respiratory viruses, Vol.10(3), pp.192-204
Publisher: Wiley
Number of pages: 13
Grant note: 11/46/12 / National Institute for Health Research; National Institute for Health Research (NIHR) F. Hoffmann-La Roche, Switzerland; Hoffmann-La Roche
Identifiers: 9913745908331
Academic Unit: Alfaisal University
Language: English
Resource Type: Journal article