Abstract
Abstract
The air suspension technique was adopted to deposit 5-methoxypsoralen (5-MOP) with different water-soluble polymers and/or surfactants on lactose. Formulations showing acceptable dissolution behaviour were evaluated for their absorption rates by demonstrating their toxicities compared to pure drug by the LD50 method. Plots of 5-MOP dissolved at different time intervals up to 120 minutes against the LD50 values showed rank-order correlation. Formulation contains 5-MOP, PEG 6000, dioctyl sodium sulfosuccinate and lactose, in 1:2:0.1:6.9 ratio, would be a formulation of choice.