Abstract
Helicobacter pylori
are well acknowledged as a major cause of gastrointestinal ailments and gastric cancers. Therefore, the present study aimed to investigate the potential
in vitro
activity of
Desmostachya bipinnata
against
H. pylori
, focusing on the determination of the most active extract responsible for the anti-helicobacter activity to produce new active drug from natural source.
Desmostachya bipinnata
total alcohol and successive extracts were
in vitro
tested against
H. pylori
. All extracts showed promising anti
Helicobacter pylori
activities. The most effective extract was diethyl ether extract, it showed 75% growth inhibition of the clinical Isolates bacterial
Helicobacter pylori
, in addition it showed high count reduction on the selected organisms in the different concentrations used (2xMIC, MIC & ½ MIC) compared with the untreated controls as well as the other extracts (chloroform, ethyl acetate and n-butanol). The oral median lethal dose (LD
50
) of the alcohol extract of the plant by doses up to 5000 mg/kg didn’t showed any mortality or morbidity, in addition no side effects were recorded on both liver and kidney functions this means that the extract was safe for use.