Abstract
In this article, four new Schiff base complexes of Mn(II), Co(II), Ni(II) and Cu(ll) complexes have been synthesized with two different compositions as [M(L)(2)Cl-2] center dot nH(2)O and [M(L)(2)(H2O)(2)]Cl-2 center dot nH(2)O [where L1 = benzoin-o-amino benzoic acid (aromatic beta amino acid) and L2 = benzoin bromo-o-amino benzoic acid (aromatic beta amino acid); M = Mn-II, Co-II, Ni-II and Cu-II; n = 1, 2 and 4]. These Schiff base complexes were discussed by many tool of analyses like elemental analysis, magnetic susceptibility, molar conductance, mass spectra, infrared spectra "IR," proton nuclear magnetic resonance "H-1-NMR," electronic spectral and thermogravimetric analysis (TG/DTG). These complexes have an electrolytic nature within range of 78-174 Omega(1) cm(-1) mol(-1) based on conductance measurements. Magnetic moment and electronic spectral results deduced that the geometry of Mn2+, Co2+ and Ni2+ and Cu2+ complexes has an octahedral configuration. The number of coordinated and uncoordinated water molecules for the synthesized complexes were calculated based on the thermal analysis technique. The kinetic thermodynamic data were estimated by using commonly integral equations of Horowitz-Metzger (HM) and Coats-Redfern (CR). In vitro the antimicrobial activity of both free L1 and L2 ligands in comparable with their metal complexes were evaluated. This study was strengthen by molecular docking against three protein receptors, which attributing to selected organisms already used in vitro study.