Abstract
The proprotein convertases (PCs) are involved in variety of cellular precursors in the secretory pathway. Polymorphisms in proprotein convertase subtilisin/kexin type 1 (PCSK1) have been associated with adult and childhood obesity. In this work non synonymous SNPs of the PCSK1 gene were retrieved from the dbSNP database. In order to predict the damaging or deleterious nsSNPs, multiple consensus tools were employed by using online tool VEP. Further we also employed SNP-GO tools to predict pathogenic nonsynonymous SNPs. Mutants like D176Y, E345A, G228V, G308E, G310R, G440E, G442R, R110C, S382L, W130S and W404R have shown deleterious and highest pathogenicity. These predicted deleterious and pathogenic nsSNPs are expected to have impending functional influence and may contribute in understanding the functional roles of PCSK1 gene associated with obesity.